Comments on: Post-Marketing Surveillance of Vaccines [Part 1 of 4] http://studentdoctor.net/2008/04/post-marketing-surveillance-of-vaccines-part-1-of-4/ A nonprofit educational organization Thu, 09 Feb 2012 15:12:52 -0500 hourly 1 By: Bayrak http://studentdoctor.net/2008/04/post-marketing-surveillance-of-vaccines-part-1-of-4/#comment-1465 Bayrak Wed, 23 Apr 2008 07:54:58 +0000 http://studentdoctor.net/blog/2008/04/12/post-marketing-surveillance-of-vaccines-part-1-of-4/#comment-1465 do you know any information about this subject in other languages? do you know any information about this subject in other languages?

]]> By: Belemba http://studentdoctor.net/2008/04/post-marketing-surveillance-of-vaccines-part-1-of-4/#comment-1466 Belemba Thu, 17 Apr 2008 12:02:20 +0000 http://studentdoctor.net/blog/2008/04/12/post-marketing-surveillance-of-vaccines-part-1-of-4/#comment-1466 Despite widespread concerns that MMR immunisation causes autism, no study has ever looked at serological markers of brain damage following immunisation. Yet many such studies have been done with serological markers of brain damage in anaesthesia (eg after bypass) and delayed childbirth, motor accidents etc. One can only wonder why such simple studies have not been done which would only require small numbers. Small scale studies with such specific markers would be far more powerful than large scale community studies with fuzzy markers. One could test for markers of brain injury and also test for antibodies against brain proteins over 8 weeks post immunisation. The antibodies could look for eg anti-myelin basic protein which is frequently elevated in autism. Br J Anaesth. 2000 Mar;84(3):304-7. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=10793601&dopt=Abstract Page 380 Table 3 gives a list of potential biochemical markers: Glia- S100, myelin basic protein (MBP), Glial fibrillary acidic protein (GFAP) Neurones- Neuron specific enolase (NSE), adenylate kinase (AK), CPK brain isoform (CPK-BB) Guanine nucleotide binding protein G0, calbidin-D. Lactate dehydrogenase (LDH), glutamate Inflammatory cells- IL-6m transforming growth factor-Beta, adhesion molecules (ICAM-1, E-selectin, neural cell adhesion molecule-NCAM) Metabolic- Lactate, Cu-Zn superoxide dismutase (CuZn-SOD). Now, you're not really looking at oxidative stress so the 2 metabolic ones are no help. You are looking at autoimmune mechanisms, so you're going to need to test for MBP, and later on antibodies to it, and probably also choose a very specific neuron marker, and perhaps antibodies to that. NSE sounds interesting. CK-BB - I don't know if the assay is difficult in the presence of CK-MM from skeletal muscle. There are old papers on CK-BB in closed head injury in kids but I haven't looked any of it up lately. The safety of MMR until these simple safety tests have been done. Despite widespread concerns that MMR immunisation causes autism, no study has ever looked at serological markers of brain damage following immunisation. Yet many such studies have been done with serological markers of brain damage in anaesthesia (eg after bypass) and delayed childbirth, motor accidents etc.

One can only wonder why such simple studies have not been done which would only require small numbers. Small scale studies with such specific markers would be far more powerful than large scale community studies with fuzzy markers.

One could test for markers of brain injury and also test for antibodies against brain proteins over 8 weeks post immunisation. The antibodies could look for eg anti-myelin basic protein which is frequently elevated in autism.

Br J Anaesth. 2000 Mar;84(3):304-7.

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=10793601&dopt=Abstract
Page 380 Table 3 gives a list of potential biochemical markers:
Glia- S100, myelin basic protein (MBP), Glial fibrillary acidic protein (GFAP)
Neurones- Neuron specific enolase (NSE), adenylate kinase (AK), CPK brain isoform (CPK-BB) Guanine nucleotide binding protein G0, calbidin-D. Lactate dehydrogenase (LDH), glutamate
Inflammatory cells- IL-6m transforming growth factor-Beta, adhesion molecules (ICAM-1, E-selectin, neural cell adhesion molecule-NCAM)
Metabolic- Lactate, Cu-Zn superoxide dismutase (CuZn-SOD).

Now, you’re not really looking at oxidative stress so the 2 metabolic ones are no help.

You are looking at autoimmune mechanisms, so you’re going to need to test for MBP, and later on antibodies to it, and probably also choose a very specific neuron marker, and perhaps antibodies to that. NSE sounds interesting. CK-BB – I don’t know if the assay is difficult in the presence of CK-MM from skeletal muscle. There are old papers on CK-BB in closed head injury in kids but I haven’t looked any of it up lately.

The safety of MMR until these simple safety tests have been done.

]]>